Editorial: Myokines, Adipokines, Cytokines in Muscle Pathophysiology

Role of Cytokines in Pathophysiology of Asthma

The worldwide incidence, morbidity and mortality of asthma are increasing dramatically. It is one of the most common disorders encountered in clinical medicine in both children and adults. It affects approximately 5% of the adult population in the western world and its reported incidence is increasing vigorously in many developed nations. A network of a novel mediator known as ‘pleiotropic cyto...

Skeletal Muscle, Myokines and Health

Accumulating epidemiological data suggest that a physically active life plays an independent role in the protection against metabolic syndrome, type 2 diabetes, cardiovascular diseases, cancer and dementia. For most of the last century, researchers sought a link between muscle contraction and humoral changes in the form of an 'exercise factor', which could be released from skeletal muscle durin...

Metabolic Adaptation in Obesity and Type II Diabetes: Myokines, Adipokines and Hepatokines

Obesity and type II diabetes are characterized by insulin resistance in peripheral tissues. A high caloric intake combined with a sedentary lifestyle is the leading cause of these conditions. Whole-body insulin resistance and its improvement are the result of the combined actions of each insulin-sensitive organ. Among the fundamental molecular mechanisms by which each organ is able to communica...

Editorial: Mesothelial Physiology and Pathophysiology

Modulation of adipokines and cytokines in gestational diabetes and macrosomia.

CONTEXT/OBJECTIVE Not much is known about the implication of adipokines and different cytokines in gestational diabetes mellitus (GDM) and macrosomia. The purpose of this study was to assess the profile of these hormones and cytokines in macrosomic babies, born to gestational diabetic women. DESIGN/SUBJECTS A total of 59 women (age, 19-42 yr) suffering from GDM with their macrosomic babies (4...